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S4) between neurons and glia contributes 50-60% of glutamate neurotransmitter (12, 13, 20) with intracellular sources such as glycolysis supplying the remainder

Importantly, we found that patients who received lidocaine administered by the W/O technique required less tramadol than patients who received a bolus injection of lidocaine, suggesting that lidocaine administration by the W/O technique may reduce the dosage of opioid analgesic used

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